Applied Quantum Chemistry for Oncology

Triplet State Technology’s Device May Improve Cancer Treatment Outcomes

Triplet State Technology in association with the UCLA Department of Radiation Oncology is pioneering an advance in quantum chemistry that holds promise to improve any cancer treatment whose primary action is via free radicals.

The clinical efficacy of radiation therapy is mechanistically linked to radiation-induced free radicals that cause cell injury through direct and indirect mechanisms. Free radical reaction dynamics in a cell come under many influences, but these can be manipulated by weak magnetic fields that influence singlet/triplet state interconversion. We demonstrate that the external presence of a magnetic field enhances radiation-induced cancer cell injury and death in vivo and in vitro. 

Animal experiments employing the Sandstrom method. LLC cells were grafted into the leg of syngeneic C57BL/6 (a) or weakly allogeneic C3H (b) mice on Day -4. The legs were mock treated or irradiated with 6 Gy with or without exposure to EMF (simultaneously plus 30min post-irradiation).  Tumor growth was monitored by caliper measurements

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9. Iwamoto K, Sandstrom RE, Bryan M, Liu Y, Elgart SR, Sheng K, Steinberg ML, McBride W, Low D.  Weak Magnetic Fields Enhance the Efficacy of Radiation Therapy.   Adv Radiat Oncol. 2021 Jan 16;6(3):100645. 9.

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